SELNICK, H. G. : rechercher sur Z-Library

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1

Preparation of 3-amino-1,4-benzodiazepin-2-ones via direct azidation with trisyl azide

John W. Butcher, Nigel J. Liverton, Harold G. Selnick, Jason M. Elliot, Garry R. Smith, Andrew J. Tebben, David A. Pribush, John S. Wai, David A. Claremon

Journal:

Tetrahedron Letters

Année:

1996

Langue:

english

Fichier:

PDF, 177 KB

english, 1996

2

Inhibition of cap (m7GpppXm)-dependent endonuclease of influenza virus by 4-substituted 2,4-dioxobutanoic acid compounds.

Tomassini, J, Selnick, H, Davies, M E, Armstrong, M E, Baldwin, J, Bourgeois, M, Hastings, J, Hazuda, D, Lewis, J, McClements, W

Journal:

Antimicrobial Agents and Chemotherapy

Année:

1994

Langue:

english

Fichier:

PDF, 2.16 MB

english, 1994

3

A short radiosynthesis of 6-[C3H3]-dorzolamide at very high specific activity and optical purity

W.-s. Eng, H. D. Burns, G. S. Ponticello, H. G. Selnick

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1996

Langue:

english

Fichier:

PDF, 452 KB

english, 1996

4

ChemInform Abstract: Preparation and Evaluation of 1,3-Diaminocyclopentane-Linked Dihydropyrimidinone Derivatives as Selective α1a-Receptor Antagonists.

James C. Barrow, Kristen L. Glass, Harold G. Selnick, Roger M. Freidinger, Raymond S. L. Chang, Stacey S. O'Malley, Carla Woyden

Journal:

Année:

2000

Fichier:

PDF, 41 KB

2000

5

ChemInform Abstract: A Facile Three-Step Synthesis of 1,2-Amino Alcohols Using the Ellman Homochiral tert-Butylsulfinamide.

James C. Barrow, Phung L. Ngo, Janetta M. Pellicore, Harold G. Selnick, Philippe G. Nantermet

Journal:

Année:

2001

Fichier:

PDF, 32 KB

2001

6

Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1

James C. Barrow, Kenneth E. Rittle, Phung L. Ngo, Harold G. Selnick, Samuel L. Graham, Steven M. Pitzenberger, Georgia B. McGaughey, Dennis Colussi, Ming-Tain Lai, Qian Huang, Katherine Tugusheva, Amy

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 302 KB

english, 2007

7

Cover Picture: Design and Synthesis of 2,3,5-Substituted Imidazolidin-4-one Inhibitors of BACE-1 (ChemMedChem 7/2007)

James C. Barrow, Kenneth E. Rittle, Phung L. Ngo, Harold G. Selnick, Samuel L. Graham, Steven M. Pitzenberger, Georgia B. McGaughey, Dennis Colussi, Ming-Tain Lai, Qian Huang, Katherine Tugusheva, Amy

Journal:

Année:

2007

Fichier:

PDF, 31 KB

2007

8

Evolution of Tertiary Carbinamine BACE-1 Inhibitors: Aβ Reduction in Rhesus CSF upon Oral Dosing

Philippe G. Nantermet, Hemaka A. Rajapakse, Mathew G. Stanton, Shaun R. Stauffer, James C. Barrow, Allison R. Gregro, Keith P. Moore, Melissa A. Steinbeiser, John Swestock, Harold G. Selnick, Samuel L

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 399 KB

english, 2009

9

β-Secretase (BACE-1) inhibitors: Accounting for 10s loop flexibility using rigid active sites

Georgia B. McGaughey, Dennis Colussi, Samuel L. Graham, Ming-Tain Lai, Sanjeev K. Munshi, Philippe G. Nantermet, Beth Pietrak, Hemaka A. Rajapakse, Harold G. Selnick, Shaun R. Stauffer, M. Katharine H

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 240 KB

english, 2007

10

P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold

Philippe G. Nantermet, Christopher S. Burgey, Kyle A. Robinson, Janetta M. Pellicore, Christina L. Newton, James Z. Deng, Harold G. Selnick, S. Dale Lewis, Bobby J. Lucas, Julie A. Krueger, Cynthia Mi

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2005

Langue:

english

Fichier:

PDF, 297 KB

english, 2005

11

Design, synthesis, and SAR of macrocyclic tertiary carbinamine BACE-1 inhibitors

Stacey R. Lindsley, Keith P. Moore, Hemaka A. Rajapakse, Harold G. Selnick, Mary Beth Young, Hong Zhu, Sanjeev Munshi, Lawrence Kuo, Georgia B. McGaughey, Dennis Colussi, Ming-Chih Crouthamel, Ming-Ta

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2007

Langue:

english

Fichier:

PDF, 170 KB

english, 2007

12

SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition

Hemaka A. Rajapakse, Philippe G. Nantermet, Harold G. Selnick, James C. Barrow, Georgia B. McGaughey, Sanjeev Munshi, Stacey R. Lindsley, Mary Beth Young, Phung L. Ngo, M. Katherine Holloway, Ming-Tai

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 540 KB

english, 2010

13

Preparation and trapping of 3-lithium-O-lithiophenoxide

Harold G. Selnick, Michelle L. Bourgeois, John W. Butcher, Ellen M. Radzilowski

Journal:

Tetrahedron Letters

Année:

1993

Langue:

english

Fichier:

PDF, 236 KB

english, 1993

14

The synthesis of dihydrofurano[2,3-b]thiopyrans, thiepins and thiophenes

H.G. Selnick, L.M. Brookes

Journal:

Tetrahedron Letters

Année:

1989

Langue:

english

Fichier:

PDF, 230 KB

english, 1989

15

The synthesis of dihydrothieno[2,3-b]thiophenes by a metal-halogen exchange initiated intramolecular acylation

Harold G. Selnick, Ellen M. Radzilowski, Gerald S. Ponticello

Journal:

Tetrahedron Letters

Année:

1991

Langue:

english

Fichier:

PDF, 231 KB

english, 1991

16

Enynones in organic synthesis. I. Spiroannulation by tandem oxy-cope rearrangement-electrocyclic ring closure

Peter A. Jacobi, Lisa M. Armacost, Joseph I. Kravitz, Michael J. Martinelli, Harold G. Selnick

Journal:

Tetrahedron Letters

Année:

1988

Langue:

english

Fichier:

PDF, 288 KB

english, 1988

17

A novel degradation in the avermectin series: A stereospecific osmylation reaction

Harold G. Selnick, Samuel J. Danishefsky

Journal:

Tetrahedron Letters

Année:

1987

Langue:

english

Fichier:

PDF, 182 KB

english, 1987

18

A facile three-step synthesis of 1,2-amino alcohols using the Ellman homochiral tert-butylsulfinamide

James C Barrow, Phung L Ngo, Janetta M Pellicore, Harold G Selnick, Philippe G Nantermet

Journal:

Tetrahedron Letters

Année:

2001

Langue:

english

Fichier:

PDF, 85 KB

english, 2001

19

Potent thrombin inhibitors via a 20-membered ring olefin metathesis macrocyclization

Philippe G. Nantermet, Harold G. Selnick

Journal:

Tetrahedron Letters

Année:

2003

Langue:

english

Fichier:

PDF, 195 KB

english, 2003

20

Preparation and evaluation of 1,3-diaminocyclopentane-linked dihydropyrimidinone derivatives as selective α1a-receptor antagonists

James C Barrow, Kristen L Glass, Harold G Selnick, Roger M Freidinger, Raymond S.L Chang, Stacey S O'Malley, Carla Woyden

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 155 KB

english, 2000

21

Discovery and initial structure–Activity relationships of trisubstituted ureas as thrombin receptor (PAR-1) antagonists

James C Barrow, Philippe G Nantermet, Harold G Selnick, Kristen L Glass, Phung L Ngo, Mary Beth Young, Janetta M Pellicore, Michael J Breslin, John H Hutchinson, Roger M Freidinger, Cindra Condra, Jer

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2001

Langue:

english

Fichier:

PDF, 180 KB

english, 2001

22

Pharmacokinetic optimization of 3-amino-6-chloropyrazinone acetamide thrombin inhibitors. implementation of P3 pyridine N-Oxides to deliver an orally bioavailable series containing P1 N-Benzylamides

Christopher S. Burgey, Kyle A. Robinson, Terry A. Lyle, Philippe G. Nantermet, Harold G. Selnick, Richard C.A. Isaacs, S.Dale Lewis, Bobby J. Lucas, Julie A. Krueger, Rominder Singh, Cynthia Miller-St

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 255 KB

english, 2003

23

Selective α1a adrenergic receptor antagonists based on 4-aryl-3,4-dihydropyridine-2-ones

Philippe G Nantermet, James C Barrow, Harold G Selnick, Carl F Homnick, Roger M Freidinger, Raymond S.L Chang, Stacey S O'Malley, Duane R Reiss, Theodore P Broten, Richard W Ransom, Douglas J Pettibon

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 144 KB

english, 2000

24

ChemInform Abstract: An Improved Procedure for the Cyanation of Aryl Triflates: A Convenient Synthesis of 6-Cyano-1,2,3,4-tetrahydroisoquinoline.

H. G. SELNICK, G. R. SMITH, A. J. TEBBEN

Journal:

Année:

1995

Fichier:

PDF, 29 KB

1995

25

ChemInform Abstract: Preparation of 3-Amino-1,4-benzodiazepin-2-ones via Direct Azidation with Trisyl Azide.

J. W. BUTCHER, N. J. LIVERTON, H. G. SELNICK, J. M. ELLIOT, G. R. SMITH, A. J. TEBBEN, D. A. PRIBUSH, J. S. WAI, D. A. CLAREMON

Journal:

Année:

1996

Fichier:

PDF, 34 KB

1996

26

4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121)

Elliott, Jason M., Selnick, Harold G., Claremon, David A., Baldwin, John J., Buhrow, Susan A., Butcher, John W., Habecker, Charles N., King, Stella W., Lynch, Joseph J.

Journal:

Journal of Medicinal Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 443 KB

english, 1992

27

In Vitro and in Vivo Evaluation of Dihydropyrimidinone C-5 Amides as Potent and Selective α 1A Receptor Antagonists for the Treatment of Benign Prostatic Hyperplasia

Barrow, James C., Nantermet, Philippe G., Selnick, Harold G., Glass, Kristen L., Rittle, Kenneth E., Gilbert, Kevin F., Steele, Thomas G., Homnick, Carl F., Freidinger, Roger M., Ransom, Rick W., Klin

Journal:

Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 329 KB

english, 2000

28

Discovery and Evaluation of Potent P 1 Aryl Heterocycle-Based Thrombin Inhibitors

Young, Mary Beth, Barrow, James C., Glass, Kristen L., Lundell, George F., Newton, Christina L., Pellicore, Janetta M., Rittle, Kenneth E., Selnick, Harold G., Stauffer, Kenneth J., Vacca, Joseph P.,

Journal:

Journal of Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 350 KB

english, 2004

29

In vitro study on [3H]THK523 binding to brain tissues of Alzheimer's disease

Zhizhen Zeng, Tsing-Bau Chen, Patricia Miller, Brett Connolly, Harold G. Selnick, Scott Pollack, Cyrille Sur, Terence Hamill

Journal:

Alzheimer's & Dementia

Année:

2012

Langue:

english

Fichier:

PDF, 138 KB

english, 2012

30

Total synthesis of zincophorin

Danishefsky, Samuel J., Selnick, Harold G., Zelle, Robert E., DeNinno, Michael P.

Journal:

Journal of the American Chemical Society

Année:

1988

Langue:

english

Fichier:

PDF, 1.29 MB

english, 1988

31

The total synthesis of the aglycon of avermectin A1a

Danishefsky, Samuel J., Armistead, David M., Wincott, Francine E., Selnick, Harold G., Hungate, Randall

Journal:

Journal of the American Chemical Society

Année:

1987

Langue:

english

Fichier:

PDF, 423 KB

english, 1987

32

9-Hydroxyazafluorenes and Their Use in Thrombin Inhibitors

Stauffer, Kenneth J., Williams, Peter D., Selnick, Harold G., Nantermet, Philippe G., Newton, Christina L., Homnick, Carl F., Zrada, Matthew M., Lewis, S. Dale, Lucas, Bobby J., Krueger, Julie A., Pie

Journal:

Journal of Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 223 KB

english, 2005

33

Discovery and X-ray Crystallographic Analysis of a Spiropiperidine Iminohydantoin Inhibitor of β-Secretase ‡

Barrow, James C., Stauffer, Shaun R., Rittle, Kenneth E., Ngo, Phung L., Yang, ZhiQiang, Selnick, Harold G., Graham, Samuel L., Munshi, Sanjeev, McGaughey, Georgia B., Holloway, M. Katharine, Simon, A

Journal:

Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 380 KB

english, 2008

34

An Improved Procedure for the Cyanation of Aryl Triflates: A Convenient Synthesis of 6-Cyano-1,2,3,4-Tetrahydroisoquinoline

Selnick, H. G., Smith, G. R., Tebben, A. J.

Journal:

Synthetic Communications

Année:

1995

Langue:

english

Fichier:

PDF, 272 KB

english, 1995

35

Total synthesis of (.+-.)-gnididione and (.+-.)-isognididione

Jacobi, Peter A., Selnick, Harold G.

Journal:

Journal of Organic Chemistry

Année:

1990

Langue:

english

Fichier:

PDF, 1.13 MB

english, 1990

36

In vitro characterization of [3H]-T808 (tau PET tracer) binding in human brain tissues of Alzheimer's disease

Zeng, Zhizhen, Chen, Tsing-Bau, Miller, Patricia, O'Malley, Stacey, Connolly, Brett, Bennacef, Idriss, Selnick, Harold G., Pollack, Scott, Sur, Cyrille, Hostetler, Eric

Journal:

Alzheimer's & Dementia

Année:

2013

Langue:

english

Fichier:

PDF, 261 KB

english, 2013

37

(E)-Alkenes as replacements of amide bonds: Development of novel and potent acyclic CGRP receptor antagonists

Kim, June J., Wood, Michael R., Stachel, Shawn J., de Leon, Pablo, Nomland, Ashley, Stump, Craig A., McWherter, Melody A., Schirripa, Kathy M., Moore, Eric L., Salvatore, Christopher A., Selnick, Haro

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2014

Langue:

english

Fichier:

PDF, 1.12 MB

english, 2014

38

In vitro characterization of [3H]-T808 (tau PET tracer) binding in human brain tissues in Alzheimer's disease

Chen, Tsing-Bau, Zeng, Zhizhen, Miller, Patricia, O'Malley, Stacey, Connolly, Brett, Bennacef, Idriss, Selnick, Harold G., Pollack, Scott, Sur, Cyrille, Hostetler, Eric

Journal:

Alzheimer's & Dementia

Année:

2013

Langue:

english

Fichier:

PDF, 152 KB

english, 2013

39

In vitro study on [3H]THK523 binding to brain tissues of Alzheimer's disease

Zeng, Zhizhen, Chen, Tsing-Bau, Miller, Patricia, Connolly, Brett, Selnick, Harold G., Pollack, Scott, Sur, Cyrille, Hamill, Terence

Journal:

Alzheimer's & Dementia

Année:

2012

Langue:

english

Fichier:

PDF, 126 KB

english, 2012

40

Bis heteroannulation. 7. Total syntheses of (.+-.)-gnididione and (.+-.)-isognididione

Jacobi, Peter A., Selnick, Harold G.

Journal:

Journal of the American Chemical Society

Année:

1984

Langue:

english

Fichier:

PDF, 318 KB

english, 1984

41

Discovery of Oxadiazoyl Tertiary Carbinamine Inhibitors of β-Secretase (BACE-1) †

Rajapakse, Hemaka A., Nantermet, Philippe G., Selnick, Harold G., Munshi, Sanjeev, McGaughey, Georgia B., Lindsley, Stacey R., Young, Mary Beth, Lai, Ming-Tain, Espeseth, Amy S., Shi, Xiao-Ping, Colus

Journal:

Journal of Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 124 KB

english, 2006

42

A systematic degradation of zincophorin: a stereoselective synthesis of the C17-C25 fragment

Zelle, Robert E., DeNinno, Michael P., Selnick, Harold G., Danishefsky, Samuel J.

Journal:

Journal of Organic Chemistry

Année:

1986

Langue:

english

Fichier:

PDF, 747 KB

english, 1986

43

Class III Antiarrhythmic Activity in Vivo by Selective Blockade of the Slowly Activating Cardiac Delayed Rectifier Potassium Current I Ks by ( R )-2-(2,4- Trifluoromethyl)- N -[2-oxo-5-phenyl- 1-(2,2,2-trifluoroethyl)-2,3-dihydro- 1 H -benzo[ e ][1,4]diazepin-3-yl]acetamide

Selnick, Harold G., Liverton, Nigel J., Baldwin, John J., Butcher, John W., Claremon, David A., Elliott, Jason M., Freidinger, Roger M., King, Stella A., Libby, Brian E., McIntyre, Charles J., Pribush

Journal:

Journal of Medicinal Chemistry

Année:

1997

Langue:

english

Fichier:

PDF, 100 KB

english, 1997

44

The total synthesis of avermectin A1a. New protocols for the synthesis of novel 2-deoxypyranose systems and their axial glycosides

Danishefsky, Samuel J., Selnick, Harold G., Armistead, David M., Wincott, Francine E.

Journal:

Journal of the American Chemical Society

Année:

1987

Langue:

english

Fichier:

PDF, 268 KB

english, 1987

45

The total synthesis of avermectin A1a

Danishefsky, Samuel J., Armistead, David M., Wincott, Francine E., Selnick, Harold G., Hungate, Randall

Journal:

Journal of the American Chemical Society

Année:

1989

Langue:

english

Fichier:

PDF, 1.92 MB

english, 1989

46

The total synthesis of zincophorin

Danishefsky, Samuel J., Selnick, Harold G., DeNinno, Michael P., Zelle, Robert E.

Journal:

Journal of the American Chemical Society

Année:

1987

Langue:

english

Fichier:

PDF, 815 KB

english, 1987

47

Design and Synthesis of Potent, Selective, and Orally Bioavailable Tetrasubstituted Imidazole Inhibitors of p38 Mitogen-Activated Protein Kinase

Liverton, Nigel J., Butcher, John W., Claiborne, Christopher F., Claremon, David A., Libby, Brian E., Nguyen, Kevin T., Pitzenberger, Steven M., Selnick, Harold G., Smith, Garry R., Tebben, Andrew, Va

Journal:

Journal of Medicinal Chemistry

Année:

1999

Langue:

english

Fichier:

PDF, 335 KB

english, 1999

48

Bis-heteroannulation. 16. A synthetic approach to geigerin

Jacobi, Peter A., Touchette, Kim M., Selnick, Harold G.

Journal:

Journal of Organic Chemistry

Année:

1992

Langue:

english

Fichier:

PDF, 1.05 MB

english, 1992

49

Estimation of Evapotranspiration Across the Conterminous United States Using a Regression With Climate and Land-Cover Data 1

Sanford, Ward E., Selnick, David L.

Journal:

JAWRA Journal of the American Water Resources Association

Année:

2013

Langue:

english

Fichier:

PDF, 3.58 MB

english, 2013

50

Erratum

Sanford, Ward E., Selnick, David L.

Journal:

JAWRA Journal of the American Water Resources Association

Année:

2013

Langue:

english

Fichier:

PDF, 44 KB

english, 2013